Publications by authors named "E S Newlands"
Background: Placental-site trophoblastic tumours are a rare form of gestational trophoblastic disease and consequently information about optimum management or prognostic factors is restricted. We aimed to assess the long-term outcome of stage-adapted management by surgery, chemotherapy, or both for patients with the disorder.
Methods: 35 550 women were registered with gestational trophoblastic disease in the UK (1976-2006), of whom 62 were diagnosed with placental-site trophoblastic tumours and included, retrospectively, in the study.
Article Synopsis
- The study aimed to assess the effectiveness and safety of a treatment regimen combining paclitaxel and cisplatin alternated with paclitaxel and etoposide (TP/TE) for patients with high-risk gestational trophoblastic neoplasia (GTN).
- Among the 24 patients treated, those with prior chemotherapy who switched to TP/TE showed a survival rate of 44%, improving to 70% when excluding those who had initially failed cisplatin-based treatments.
- The treatment was well-tolerated, with only one patient stopping due to side effects, suggesting TP/TE as a viable option for heavily pretreated GTN patients.
Purpose: Raised serum beta human chorionic gonadotrophin (beta-hCG) not due to pregnancy can occur as a consequence of (1) gestational trophoblastic neoplasia (GTN), (2) non-gestational trophoblastic tumours, (3) a false-positive beta-hCG, (4) the menopause or (5) a high normal level. Accurate differentiation between these causes is vital to avoid potentially inappropriate investigations and therapies, which may induce infertility or other serious adverse events. Here we report the United Kingdom experience of patients with an elevated beta-hCG of initial uncertain cause and provide a clinical algorithm for the management of such cases.
View Article and Find Full Text PDFObjective: To evaluate the usefulness of positron emission tomography with 18-fluorodeoxyglucose (18FDG-PET) in locating residual or relapsed gestational trophoblastic neoplasia (GTN).
Study Design: The Charing Cross GTN database was screened, and 11 patients who had undergone 18FDG-PET were identified. A retrospective analysis was conducted to determine the value of this investigation as compared with other imaging modalities in clinical care.