[Comprehensive treatment of adynamic depression with the combined use of traditional psychopharmacotherapy, transcranial magnetic stimulation and virtual reality technologies].

Objective: To study the efficacy and safety of activity-dependent neuromodulation using transcranial magnetic stimulation with intermittent theta flashes (iTBS) as priming stimulation with multimodal parameters of the virtual environment (VR) for the treatment of adynamic depression in comparison with psychopharmacotherapy (PFT).

Material And Methods: The comparative study included 85 patients with adynamic depression who were randomized into four groups: iTBS + VR + PFT (=19), iTBS + PFT (=19), VR + PFT (=23), PFT (=24). The duration of therapy was 20 days, the procedures were carried out daily, with a break for weekends, followed by an assessment of side-effects and control over compliance with the patient's drinking regimen.