Publications by authors named "E S McCord"
The gut microbiome modulates immunotherapy treatment responses, and this may explain why immune checkpoint inhibitors, such as anti-PD-1, are only effective in some patients. Previous studies correlated lipopolysaccharide (LPS)-producing gut microbes with poorer prognosis; however, LPS from diverse bacterial species can range from immunostimulatory to inhibitory. Here, by functionally analysing faecal metagenomes from 112 patients with melanoma, we found that a subset of LPS-producing bacteria encoding immunostimulatory hexa-acylated LPS was enriched in microbiomes of clinical responders.
View Article and Find Full Text PDFArticle Synopsis
- Primary care providers (PCPs) struggle with disorganized information in electronic health records (EHR) while managing patients with chronic pain, which can be improved with clinical decision support (CDS) tools like the Chronic Pain OneSheet, designed to streamline patient information and support treatment decisions.
- In a study involving interviews with PCPs who use OneSheet, barriers such as limited time, resistance to new workflows, and complex displays were identified, while facilitators included its role as a central data hub and ease of access to important features.
- Recommendations to enhance OneSheet usage include simplifying displays, customizing features, and allowing broader access for patients and team members, emphasizing the need for CDS tools to align with PCP workloads and tasks.
Background: Since 2012, work-hour alcohol use (WHAU) has been prohibited in China. However, there is a lack of national data on WHAU among healthcare workers, including psychiatrists.
Methods: We collected data from psychiatrists in 41 tertiary psychiatric hospitals using an online questionnaire, which included demographics, work-related factors, WHAU, and the Alcohol Use Disorder Identification Test-Consumption (AUDIT-C).
We propose applying the "source control" model of infectious disease treatment to the management of treatment-resistant substance use disorder (SUD). We believe that this conceptual framework complements other models for understanding SUD, fills a gap in our current understanding of treatment-resistant SUD, and advances the destigmatization of SUD by reinforcing SUD as a disease similar to other medical conditions. The model also harmonizes the need for multimodal treatment and novel interventions for both acute supportive care and long-term treatment of SUD.
View Article and Find Full Text PDFMore than 40 states in the United States have established medical cannabis programs that authorize the use of cannabis for specific medical conditions. Initially, these medical cannabis programs aimed to offer compassionate care primarily for terminal or rare, untreatable conditions. However, the scope of these programs has broadened to include nonterminal and more common conditions, including various medical and mental disorders.
View Article and Find Full Text PDF