High-Intensity Focused Ultrasound Thermotherapy for Scar Treatment.

The formation of pathological scars is a common medical and aesthetic problem worldwide. Surgical interventions, burns and injuries are the most common cause. Treating these scars is a challenge for any surgeon.

The Association of a Single-Nucleotide Polymorphism in the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene With Adverse Drug Reactions, Multimorbidity, and Frailty in Older People.

Susceptibility to adverse drug reactions (ADRs), multimorbidity, and frailty are associated with human aging, yet there is wide variation in the severity and age at which individuals are afflicted. Identifying genetic markers of increased risk of this phenotype would help stratify individuals to specialist interventions. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates a cell's response to stressors, including the expression of enzymes involved in drug metabolism.

CIRCULAR EXCISION AND "PURSE-STRING" TECHNIQUE IN SURGICAL TREATMENT OF HEMANGIOMAS.

Unlabelled: Hemangiomas are the most common benign vascular lesions in childhood. Surgical removal of hemangiomas in childhood is usually delayed till intralesional blood flow spontaneously decreases, but the fibroadipose tissue and atrophic skin remain even after general involution. The aim of our study is to provide such a technique and method that can redistribute the tension around the defect after the excision and achieve complete and simple closure.

Two cases of radiation-induced cancers 20 years after treatment of first malignancies.

Studies on radiation-induced breast and thyroid cancers have demonstrated that age at exposure is a major determinant of risk, with the greatest risk being for those irradiated as children and adolescents. In measuring the outcome of treatment, the ability to provide toxicity-free survival and minimal risk of second cancer may in future be regarded as important as achieving disease-free survival or local control. Herein we present two cases of secondary cancer with good treatment outcome that occurred 20 years after treatment for primary malignancies in childhood.