Publications by authors named "E S Knyazhanskaya"
Introduction: Premenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long-term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and neurodegeneration imaging biomarkers of Alzheimer's disease (AD).
Methods: Mayo Clinic Cohort Study of Oophorectomy and Aging-2 participants were divided into early PBO (< 46 years; n = 61), and late PBO (46-49 years; n = 51) groups and were compared to referent women who did not undergo PBO (n = 119).
Article Synopsis
- Exposure to repetitive head impacts (RHI) correlates with chronic traumatic encephalopathy (CTE), which can only be diagnosed after death; the study explores the presence of a cavum septum pellucidum (CSP) in living former football players to understand its relation to RHI and potential CTE.
- The research involved 175 former players, both college and professional, and compared their CSP measurements to a control group without RHI exposure, assessing associations with cumulative head impact and traumatic encephalopathy syndrome (TES).
- Results indicated that former players had significantly higher CSP presence and ratio compared to controls, with professional players exhibiting an even greater ratio; however, there was no notable link between CSP and TES or provisional
Article Synopsis
- The Human Connectome Project for Early Psychosis (HCP-EP) studies how the brain works in people who are starting to experience psychosis, which is when someone has trouble telling what's real and what's not.
- They collected detailed information from 303 participants aged 16-35 across different hospitals in Massachusetts and Indiana.
- The study aims to help researchers understand and compare different types of psychosis, and all the data is available for other scientists to use.
Background: Multiple sclerosis (MS) is a clinically and biologically heterogenous disease with currently unpredictable progression and relapse. After the development and success of neurofilament as a cerebrospinal fluid (CSF) biomarker, there is reinvigorated interest in identifying other markers of or contributors to disease. The objective of this study is to probe the predictive potential of a panel of brain-enriched proteins on MS disease progression and subtype.
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- * A study evaluated brain structures using MRI in 170 former football players and 54 controls, assessing regions associated with CTE pathology, revealing significant reductions in cortical thickness and volume in players compared to controls.
- * Former professional players showed more pronounced brain changes than former college players, specifically in areas like the hippocampus and amygdala, indicating that exposure to head impacts has lasting effects on brain structure.