Publications by authors named "E S Kilpatrick"
Background: The Sampson-NIH and Martin-Hopkins low-density lipoprotein cholesterol (LDL-C) equations are advocated as being superior to the Friedewald calculation. However, their mathematical complexity means they may have different biological and analytical variation when tracking LDL-C in the same patient. This study has established the biological variation (BV) of calculated and directly measured LDL-C (dLDL-C) in patients taking equivalent doses of a long (atorvastatin) and short (simvastatin) half-life statin.
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- - Combined or mixed hyperlipidaemia involves high cholesterol and triglyceride levels, affecting about 1 in 100 people in the UK, often linked to conditions like metabolic syndrome or poorly controlled diabetes.
- - It can also occur due to genetic conditions like familial combined hyperlipidaemia or type III hyperlipidaemia, but cases can be confused with familial hypercholesterolaemia (FH) when triglycerides are also elevated.
- - The article details four cases of FH identified through genetic testing in patients initially thought to only have high triglycerides, emphasizing the importance of measuring low-density lipoprotein cholesterol (LDL-C) for accurate diagnosis.
This is a case of a 61-year-old lady who presented to the lipid clinic with possible familial hypercholesterolaemia (Simon Broome Criteria). She was commenced on atorvastatin; however, 4 weeks later, she developed hepatitis, and therefore her atorvastatin was discontinued. Following that, her liver function tests normalized, and she was diagnosed with statin-induced hepatitis.
View Article and Find Full Text PDFObjectives: An insulin resistant state is characteristic of patients with type 2 diabetes, polycystic ovary syndrome, and metabolic syndrome. Identification of insulin resistance (IR) is most readily achievable using formulae combining plasma insulin and glucose results. In this study, we have used data from the European Biological Variation Study (EuBIVAS) to examine the biological variability (BV) of IR using the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and the Quantitative Insulin sensitivity Check Index (QUICKI).
View Article and Find Full Text PDFObjectives: Glycated albumin (GA) has potential value in the management of people with diabetes; however, to draw meaningful conclusions between clinical studies it is important that the GA values are comparable. This study investigates the standardization of the Norudia Glycated Albumin and Lucica Glycated Albumin-L methods.
Methods: The manufacturer reported imprecision was verified by performing CLSI-EP15-A3 protocol using manufacturer produced controls.