Facile approach to N,O,S-heteropentacycles via condensation of sterically crowded 3-phenoxazin-3-one with substituted anilines.

A convenient method for the synthesis of a series of 2-(arylamino)-3-phenoxazin-3-ones based on the nucleophilic substitution reaction between sterically crowded 3-phenoxazin-3-one and arylamines performed by short-term heating of the melted reactants at 220-250 °C is described, and the compounds were characterized by means of single-crystal X-ray crystallography, NMR, UV-vis, and IR spectroscopy, as well as cyclic voltammetry. The reaction with -amino-, -hydroxy-, and -mercapto-substituted arylamines widened the scope and provided an access to derivatives of N,O- and N,S-heteropentacyclic quinoxalinophenoxazine, triphenodioxazine and oxazinophenothiazine systems.

A new heteropentacyclic system coupling sterically crowded -benzoquinone with -phenylenediamines.

The reaction between 3,5-di(-butyl)--benzoquinone 1 and -phenylenediamine performed under oxidative conditions that is highly sensitive to the reaction conditions (type of solvent, ratio of reactants, and duration of the reaction) gives rise to various derivatives of a new condensed 10-quinoxalino[3,2,1-]phenoxazin-10-one heteropentacyclic system. The reaction of 1 with -phenyl--phenylenediamine results in the formation of three phenazine-like compounds and, unexpectedly, a derivative of a new spiro[1,3]dioxole-2,2'-furanyl-1-benzo[]imidazole system. The molecular structures of the prepared compounds were authenticated by NMR, mass spectra and X-ray crystallography data.

[Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants].

The problem of food allergy to cow's milk protein in children is highly important. The aim of this study was to estimate the effect of Bifidobacterium lactis BB-12 (1х109 CFU) and Streptococcus thermophilus TH-4 (1х108 CFU) administration on gastrointestinal symptoms of cow's milk allergy in infants. We conducted an open randomized prospective clinical study.

Synthesis, molecular and electronic structures of six-coordinate transition metal (Mn, Fe, Co, Ni, Cu, and Zn) complexes with redox-active 9-hydroxyphenoxazin-1-one ligands.

A series of pseudo-octahedral metal (M = Mn, Fe, Co, Ni, Cu, Zn) complexes 4 of a new redox-active ligand, 2,4,6,8-tetra(tert-butyl)-9-hydroxyphenoxazin-1-one 3, have been synthesized, and their molecular structures determined with help of X-ray crystallography. The effective magnetic moments of complexes 4 (M = Mn, Fe, Co, and Ni) measured in the solid state and toluene solution point to the stabilization of their high-spin electronic ground states. Detailed information on the electronic structure of the complexes and their redox-isomeric forms has been obtained using density functional theory (DFT) B3LYP*/6-311++G(d,p) calculations.