Publications by authors named "E S Horton"

Hybridization and introgression are widespread in nature, with important implications for adaptation and speciation. Since heterogametic hybrids often have lower fitness than homogametic individuals, a phenomenon known as Haldane's rule, loci inherited strictly through the heterogametic sex rarely introgress. We focus on the Y-chromosomal history of guenons, African primates that hybridized extensively in the past.

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Salmon is the most commonly consumed finfish in the United States of America (USA), and the mislabeling of salmon is a widespread problem. Washington State is a global supplier of wild-caught Pacific salmon and local salmon mislabeling results in substantial economic, ecological, and cultural impacts. Previous studies in Washington State identified high levels of mislabeled salmon in both markets and restaurants, resulting in local legislation being passed that requires proper labeling of salmon products, including identifying it as wild-caught or farm-raised.

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Approximately 14.7 million US children aged 2 to 19 years are obese. This creates significant challenges to dosing medications that are primarily weight based (mg/kg) and in predicting pharmacokinetics parameters in pediatric patients.

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Article Synopsis
  • Systemic arterial properties play a crucial role in determining clinical outcomes and variations in patients with degenerative calcific aortic stenosis (AS), yet many previous studies overlooked pulsatile pressure-flow relations as a critical assessment method.
  • A retrospective study of 135 AS patients examined the relationship between pulsatile load and risk of mortality and heart failure hospital admissions using advanced modeling techniques.
  • Results show that pressure-dependent total arterial compliance is a significant predictor of mortality and adverse heart failure events, outperforming traditional measures of arterial load, suggesting that understanding arterial wall pressure can better identify high-risk patients.
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  • The poly(A) signal is critical for determining the 3' end of mature mRNA transcripts, with the common signal in humans being the AAUAAA hexamer, while a unique hexamer (AGURAA) was discovered in a deeply branching eukaryote.
  • Research showed that the AAUAAA signal is likely ancestral, appearing in at least four different eukaryotic clades, indicating its evolutionary significance.
  • Findings also highlighted that auxiliary elements influencing cleavage sites are variable and can differ within species, suggesting that the processes governing gene expression are dynamic and warrant further study for potential therapeutic applications against eukaryotic pathogens.
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