Publications by authors named "E S Edison"
Molecular Heterogeneity of Osteopetrosis in India: Report of 17 Novel Variants.
Indian J Hematol Blood Transfus
July 2024
Article Synopsis
- Osteopetrosis is a group of inherited bone disorders caused by issues with osteoclasts, affecting bone density and treatment options based on disease severity.
- A study on 31 Indian patients identified 30 genetic variants, mostly involving specific genes, with 17 being novel findings, highlighting the genetic complexity of the condition.
- Accurate genetic diagnosis is crucial for treatment decisions, such as stem cell transplantation, and can facilitate prenatal screening for affected families.
Objective: This narrative review aims to describe measures to minimise the risk of complications during percutaneous nephrolithotomy (PCNL), ureteroscopy, and retrograde intrarenal surgery.
Methods: A literature search was conducted from the PubMed/PMC database for papers published within the last 10 years (January 2012 to December 2022). Search terms included "ureteroscopy", "retrograde intrarenal surgery", "PCNL", "percutaneous nephrolithotomy", "complications", "sepsis", "infection", "bleed", "haemorrhage", and "hemorrhage".
Article Synopsis
- The study explored telomere length (TL) in patients with bone marrow failure syndromes (BMFS) compared to a healthy population and found that normal aging leads to a loss of TL.
- In a sample of 650 patients with aplastic anemia (AA), TL was significantly shorter than in healthy controls, indicating a correlation between short TL and BMFS.
- Additionally, patients with myelodysplastic syndromes (MDS) had even shorter TL compared to age-matched AA patients, highlighting the potential impact of specific conditions on telomere dynamics.
Treosulfan Exposure Predicts Thalassemia-Free Survival in Patients with Beta Thalassemia Major Undergoing Allogeneic Hematopoietic Cell Transplantation.
Clin Pharmacol Ther
January 2024
A toxicity-reduced conditioning regimen with treosulfan, fludarabine, and thiotepa in patients with high-risk β-thalassemia major has significantly improved hematopoietic stem cell transplantation (HCT) outcomes. However, complications resulting from regimen-related toxicities (RRTs), mixed chimerism, and graft rejection remain a challenge. We evaluated the dose-exposure-response relationship of treosulfan and its active metabolite S, S-EBDM, in a uniform cohort of patients with β-thalassemia major to identify whether therapeutic drug monitoring (TDM) and dose adjustment of treosulfan is feasible.
View Article and Find Full Text PDFSodium-metal batteries are promising candidates for low-cost, large-format energy storage systems. However, sodium-metal batteries suffer from high interfacial resistance between the electrodes and the solid electrolyte, leading to poor electrochemical performance. We demonstrate a sodium superionic conductor (NASICON) with an oriented porous framework of sodium aluminum titanium phosphate (NATP) fabricated by the freeze-casting technique, which shows excellent properties as a solid electrolyte.
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