Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations.

Epigenetic clocks provide an accurate molecular readout of epigenetic age and epigenetic age acceleration (EAA) derived from DNA methylation data have shown promise as biomarkers of ageing. This systematic review synthesised research on associations between EAA measures and various physiological, cognitive, social, and environmental factors. A comprehensive search strategy identified 299 publications reporting 1050 unique EAA-factor associations based on 53 methylation clocks.

Open access-enabled evaluation of epigenetic age acceleration in colorectal cancer and development of a classifier with diagnostic potential.

Aberrant DNA methylation (DNAm) is known to be associated with the aetiology of cancer, including colorectal cancer (CRC). In the past, the availability of open access data has been the main driver of innovative method development and research training. However, this is increasingly being eroded by the move to controlled access, particularly of medical data, including cancer DNAm data.

[Labor strategies of graduates of medical educational institutions: predicted risks of the medical industry].

The article presents the results of a study of the labor strategies of youth included in the personnel reproduction of regional health care. The authors of the article consider the results of a complex sociological study of graduates of educational medical organizations and specialized medical classes (focus group studies, target survey; n = 1027). The research made it possible to answer questions about the dynamics of professional motivation of young people, to determine labor strategies and reasons for choosing in life planning.

Evaluation of Epigenetic Age Acceleration Scores and Their Associations with CVD-Related Phenotypes in a Population Cohort.

We evaluated associations between nine epigenetic age acceleration (EAA) scores and 18 cardiometabolic phenotypes using an Eastern European ageing population cohort richly annotated for a diverse set of phenotypes (subsample, = 306; aged 45-69 years). This was implemented by splitting the data into groups with positive and negative EAAs. We observed strong association between all EAA scores and sex, suggesting that any analysis of EAAs should be adjusted by sex.

Pathways resilient future for developing a sustainable E85 fuel and prospects towards its applications.

The utilization of ethanol as a component of motor gasolines is an extremely effective way to increase the detonation resistance and environmental properties. In Russia, despite the existing prerequisites for the development of bioethanol industry, the real production of bioethanol is not executed, which is associated with its high price. One of the promising ways of leveling this drawback is the utilization of water-cut waste from its production, involving ethyl alcohol impurity concentrate (EAIC) instead of pure ethanol.