Publications by authors named "E S Burnevich"
Article Synopsis
- The study aimed to assess the effectiveness and safety of a combination treatment (narlaprevir/ritonavir and daclatasvir) for patients with hepatitis C genotype 1b.
- Out of 105 enrolled patients, 89.5% achieved a sustained virological response 12 weeks post-treatment, with most participants experiencing mild to moderate side effects.
- The findings suggest that this treatment combination is highly effective and well-tolerated for treating HCV in naive patients.
Exactly 30 years ago, hepatitis C virus was identified. Over the years, tremendous success has been achieved in the treatment of hepatitis C, which is currently considered to be an almost completely curable disease. The review presents the main stages in the development of hepatitis C antiviral therapy, the efficacy of various treatment regimens.
View Article and Find Full Text PDFPurpose: Hepatitis C virus (HCV) infection is a major healthcare concern in Russia, where almost 5 million individuals are viremic. Elbasvir/grazoprevir is a fixed-dose combination therapy for the treatment of HCV genotype 1 and genotype 4 infection. The present analysis aimed to assess the safety and efficacy of elbasvir/grazoprevir in individuals with HCV infection enrolled at Russian study sites in the C-CORAL study.
View Article and Find Full Text PDFRuzasvir (MK-8408, an NS5A inhibitor) and uprifosbuvir (MK-3682, a nonstructural protein 5B nucleotide inhibitor) are highly potent direct-acting antiviral agents for the treatment of hepatitis C virus (HCV) infection. A phase III clinical trial evaluating the two-drug combination of ruzasvir 60 mg plus uprifosbuvir 450 mg suggested suboptimal efficacy in certain HCV genotypes (C-BREEZE 1; NCT02759315). The aim of the present study was to evaluate the efficacy and safety of ruzasvir in combination with uprifosbuvir administered at a higher dose than that assessed in the earlier study (C-BREEZE 2: NCT02956629/Merck protocol PN041).
View Article and Find Full Text PDFAim: To investigate risk factors of unfavorable prognosis in patients with chronic hepatitis C (CHC), including liver cirrhosis (LC), decompensated cirrhosis, hepatocellular carcinoma (HCC), cryoglobulinemic vasculitis (CryoVas) and B-cell non-Hodgkin's lymphoma.
Materials And Methods: This was a retrospective study using data of 824 patients with CHC hospitalized between 2010 and 2016 in clinic named after E.M.