molli: A General Purpose Python Toolkit for Combinatorial Small Molecule Library Generation, Manipulation, and Feature Extraction.

The construction, management, and analysis of large molecular libraries is critical in many areas of modern chemistry. Herein, we introduce the MOLecular LIibrary toolkit, "molli", which is a Python 3 cheminformatics module that provides a streamlined interface for manipulating large libraries. Three-dimensional, combinatorial molecule libraries can be expanded directly from two-dimensional chemical structure fragments stored in CDXML files with high stereochemical fidelity.

[Chronic heart failure in the elderly].

Chronic heart failure (CHF) presents the final stage of most cardiovascular diseases. The prevalence of CHF in patients with coronary artery disease grows steadily with age. CHF causes an abrupt fall in the quality of life and working ability.