J Neurol Neurosurg Psychiatry
January 2025
Background: White matter hyperintensities (WMH) have been implicated in the pathogenesis of neuropsychiatric symptoms of dementia but the functional significance of WMH in specific white matter (WM) tracts is unclear. We investigate whether WMH burden within major WM fibre classes and individual WM tracts are differentially associated with different neuropsychiatric syndromes in a large multicentre study.
Method: Neuroimaging and neuropsychiatric data of seven memory clinic cohorts through the Meta VCI Map consortium were harmonised.
Aims: To improve quantification of valvular regurgitation, a 3D high-pulse repetition frequency Doppler (3D HPRFD) method was developed for regurgitant volume (RVol) estimation from transthoracic echocardiography (TTE). Although successfully applied and in selected clinical cases, a systematic clinical validation of 3D HPRFD has not been published. Hence, our aims were to investigate (i) feasibility of 3D HPRFD and (ii) correlation between 3D HPRFD and RVol estimates obtained by the 2D proximal isovelocity surface area (PISA) method and cardiac magnetic resonance (CMR) in patients with either aortic regurgitation (AR) or mitral regurgitation (MR).
View Article and Find Full Text PDFIndividuals with memory impairments may need to rely often on the external world (i.e. offloading).
View Article and Find Full Text PDFWe present the case of a previously healthy 11-year-old boy who developed hepatitis in the setting of regular intake of Apetamin. Apetamin is an appetite stimulant not approved by the United States Food and Drug Administration that contains cyproheptadine, lysine, and multiple B vitamins. It is illegally imported into the United States and can be purchased online.
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