Publications by authors named "E S Belousova"
Alzheimer's disease is a progressive neurodegenerative disorder characterized by mitochondria dysfunction, accumulation of beta-amyloid plaques, and hyperphosphorylated tau tangles in the brain leading to memory loss and cognitive deficits. There is currently no cure for this condition, but the potential of stem cells for the therapy of neurodegenerative pathologies is actively being researched. This review discusses preclinical and clinical studies that have used mouse models and human patients to investigate the use of novel types of stem cell treatment approaches.
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- Stem cell technology is pivotal in regenerative medicine, utilizing stem/progenitor cells for repairing or replacing damaged tissues to treat various diseases like cardiovascular and neurological disorders.
- Cell therapy works through two main mechanisms: the replacement of damaged tissue and the release of biologically active molecules that aid in tissue regeneration, but challenges like transportation complexity and immune rejection exist.
- The study focuses on the beneficial effects of proteins secreted by glial progenitor cells, showing they can reduce inflammation and support neuron survival by inhibiting harmful factors and maintaining cellular health, potentially paving the way for new therapeutic applications.
Genome compaction is one of the important subject areas for understanding the mechanisms regulating genes' expression and DNA replication and repair. The basic unit of DNA compaction in the eukaryotic cell is the nucleosome. The main chromatin proteins responsible for DNA compaction have already been identified, but the regulation of chromatin architecture is still extensively studied.
View Article and Find Full Text PDFThe KMM 4639 strain was identified as sp. based on two molecular genetic markers: ITS and β-tubulin regions. Chemical investigation of co-culture marine-derived fungi sp.
View Article and Find Full Text PDFBase excision repair (BER) is aimed at repair of damaged bases, which are the largest group of DNA lesions. The main steps of BER are recognition and removal of the aberrant base, cutting of the DNA sugar-phosphate backbone, gap processing (including dNMP insertion), and DNA ligation. The precise function of BER depends on the regulation of each step by regulatory/accessory proteins, the most important of which is poly(ADP-ribose) (PAR) polymerase 1 (PARP1).
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