[Conditions for grading the process of oleandomycin biosynthesis].

The data on the study of the relation between the activity of the oleandomycin biosynthesis and the operating and physical parameters of the fermenter are presented. A dependence for computation and selection of the aeration and agitation conditions of the oleandomycin biosynthesis in apparatus of different capacity is described.

[Effect of conditions of agitation and aeration on the biosynthesis of oleandomycin].

The data on the effect of the aeration and agitation conditions on biosynthesis of oleandomycin in 0.75, 3 and 50 m3 apparatus are presented. The relationship between the biosynthetic parameters, oxygen dissolution rate and specific power consumption for agitation was studied.

[Parameters characterizing the productivity of an inoculum of the producer of oleandomycin].

The possibility of using different criteria for estimation of the productivity of the vegetative inoculum of the oleandomycin-producing organism was studied with a purpose of providing maximum levels of the biosynthetic process. The use of the criteria of the culture respiration intensity and accumulation of the physiologically active mycelium as the main ones was shown to be advisable. The quantity and distribution of the mycelium in samples and the time course of changes in active acidity of the medium during the inoculum growth may be used as auxiliary criteria.

[The effect of aeration and agitation on tetracycline biosynthesis].

The results of the study on relation between tetracycline biosynthesis and the specific power input for agitation in pilot plant apparatus was studied. No correlation was observed between the levels of tetracycline biosynthesis and changes in the specific power input within a range of 0.6 to 2.

[Effect of mass exchange conditions on the biosynthesis of oxytetracycline].

An increase in the power input for agitation from 0.4 to 2.7 kw/m3 in oxytetracycline biosynthesis stimulated the antibiotic production due to an accelerated use of carbohydrate and nitrogen and an earlier transition of the culture to the phase of the antibiotic biosynthesis.