Publications by authors named "E S BARKER"
In recent years, post-secondary students' mental health has become an important public health concern. However, studies examining protective factors of mental health among students and during challenging times are limited. Guided by the strength-based Resilience Portfolio Model and following a group of undergraduates (N = 1004) throughout the 2020/2021 academic year, this study examined multiple domains of resilience internal assets and external resources and simultaneously tested multiple protective mechanisms for student mental health using structural equation modelling.
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- A female dog from Eastern Europe faced severe bleeding during an elective surgery due to a strongyloidiasis infection, which was initially undiagnosed.
- Despite normal examination results and blood tests, the testing revealed hyperfibrinolysis, an abnormal breakdown of blood clots, linked to this infection.
- Treatment with ivermectin resolved the bleeding issue, marking a unique case of transient hyperfibrinolysis specifically caused by Strongyloides stercoralis in dogs, suggesting it as a rare cause of this condition when other common causes have been ruled out.
The calcium-sensing receptor (CaSR) plays a key role in calcium homeostasis, and small-molecule and peptide positive allosteric modulators (PAMs) of CaSR, so-called calcimimetics, are used in the treatment of hyperparathyroidism and hypocalcemic disorders. In this study, four monovalent nanobodies - representing four distinct nanobody families with CaSR PAM activity - were subjected to elaborate pharmacological profiling at the receptor. While Nb5 displayed negligible PAM activity at CaSR in all assays, Nb4, Nb10 and Nb45 all potently potentiated Ca-evoked signalling through a myc epitope-tagged CaSR expressed in HEK293 or HEK293T cells in Gα and Gα protein activation assays and in a Ca/Fluo-4 assay.
View Article and Find Full Text PDFFMS-like tyrosine kinase 3 (FLT3) mutations are genetic changes found in approximately thirty percent of patients with acute myeloid leukemia (AML). FLT3 mutations in AML represent a challenging clinical scenario characterized by a high rate of relapse, even after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The advent of FLT3 tyrosine kinase inhibitors (TKIs), such as midostaurin and gilteritinib, has shown promise in achieving complete remission.
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- ASCEND PLUS is a large clinical trial in the UK aimed at preventing cardiovascular events in individuals with type 2 diabetes by using oral semaglutide, emphasizing a decentralized recruitment and follow-up method.
- The trial significantly involved patient and public input (PPIE) throughout its design and implementation, utilizing focus groups and an advisory group to ensure diverse perspectives were included.
- Results from the PPIE activities influenced key trial features, such as providing participants with flexible options for the screening process and creating user-friendly information materials, which were refined based on feedback from the advisory group.