Insights into the use of DNA content in head and neck squamous cell carcinoma as a method for patient stratification and targeted therapy: Revisiting old concepts and exploring new possibilities.

Background: This review aimed to emphasize the implications of DNA content in head and neck squamous cell carcinoma (HNSCC), focusing on its predictive value, role in patient stratification, and potential as a therapeutic target for this malignancy.

Methods: A narrative review of the literature was conducted through electronic database searches.

Results: In conventional HNSCC, aneuploid tumors are associated with increased lymph node metastasis, locoregional recurrences, poor response to radiotherapy and chemotherapy, and worse prognosis.

Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers.

Erythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes, especially in the upper gastrointestinal tract. The Eph/ephrin system has been described as a tumor suppressor in duodenal cancer, while in esophageal, gastric, hepatic, and pancreatic cancer, the system has been related to tumor progression.

Interplay between miRNA expression and glucose metabolism in oral squamous cell carcinoma.

Objective: Given the urgent need for improved diagnostic and therapeutic strategies in oral squamous cell carcinoma (OSCC), this review aims to explore the intricate interplay between OSCC and alterations in glucose metabolism, with a particular focus on the pivotal role of microRNAs (miRNAs) in this context.

Material And Methods: Data were extracted from a vast literature survey by using PubMed, Embase, and Web of Science search engines with relevant keywords.

Results: In OSCC, miRNAs exert regulatory control over the expression of genes involved in glucose metabolism pathways.