Publications by authors named "E Russell Esposito"

Spectrochemical analysis of trace elements in complex matrices is crucial across various fields of science, industry, and technology. However, this analysis is often hindered by background interference and the challenge of detecting ultralow analyte concentrations. Surface Enhanced Infrared Absorption (SEIRA) spectroscopy is emerging as a viable technique to address these challenges as it can successfully reveal soluble and unmodified analytes in a label-free manner through their interactions with a bioreceptor following site-specific labeling with small infrared-active probes.

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Article Synopsis
  • Heparanase is a key enzyme in the breakdown of heparan sulfate, contributing to tumor growth and metastasis, making it a target for cancer treatments.
  • Researchers synthesized specific trisaccharides and a tetrasaccharide that inhibit heparanase activity, focusing on glycol-split versions as potential inhibitors.
  • Studies using STD NMR and molecular docking revealed that these glycol-split trisaccharides had stronger binding and inhibitory effects against heparanase compared to their intact forms, providing insight into their mechanisms.
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Peptide-based self-assembled nanosystems show great promise as non-viral gene and siRNA delivery vectors. In the current study, we designed and functionalized nanofibers for the delivery of siRNA, targeting and silencing EGFR gene overexpressed in triple-negative breast cancer. The nanofiber-mediated siRNA delivery was characterized in terms of zeta potential, morphology, and structural stability by circular dichroism spectroscopy.

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Purulent pericarditis is rare condition in the modern era of antibiotics. However, it is a serious condition as it has an accelerated progression and is difficult to diagnose due to its nonspecific clinical presentation, resulting in high mortality. Herein, we present a case in which a 36-year-old male patient with otherwise unremarkable medical history developed abdominal sepsis complicated by purulent pericarditis post-appendectomy.

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