Publications by authors named "E Ruiz-Mateos"
Long-term control of viral replication relies on the efficient differentiation of memory T cells into effector T cells during secondary immune responses. Recent findings have identified T cell precursors for both memory and exhausted T cells, suggesting the existence of progenitor-like effector T cells. These cells can persist without antigenic challenge but expand and acquire effector functions upon recall immune responses.
View Article and Find Full Text PDFCorrection: Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients.
PLoS One
November 2024
Article Synopsis
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Elite controllers (ECs), a unique group of people with HIV (PWH), exhibit remarkable control of viral replication in the absence of antiretroviral therapy. In this study, we comprehensively characterized the NK cell repertoire in ECs after long-term viral control. Phenotypic profiling of NK cells revealed profound differences compared with other PWH, but marked similarities to uninfected individuals, with a distinctive prevalence of NKG2C+CD57+ memory-like NK cells.
View Article and Find Full Text PDFArticle Synopsis
- The study measured plasma cytokine levels in 30 elite controllers (EC) of HIV, comprising 15 transient controllers and 15 persistent controllers.
- Results showed that PWH had higher cytokine levels compared to HIV-uninfected individuals, with EC exhibiting the highest levels.
- Elevated levels of specific cytokines, IP-10 and MIG, were associated with transient controllers and could help predict the loss of viral control, offering potential biomarkers for future HIV management.
Background: Among people living with HIV-1 (PHIV), immunological non-responders (INR) experience incomplete immune recovery despite suppressive antiretroviral treatment (ART), facing more severe non-AIDS events than immunological responders (IR) due to higher chronic immune activation and inflammation (cIA/I). We analyzed the HIV-1 reservoir and immunometabolism in monocytes as a source of cIA/I.
Methods: Cross-sectional study in which 110 participants were enrolled: 25 treatment-naïve; 35 INR; 40 IR; and 10 healthy controls.