Publications by authors named "E Rubie"

Introduction: Up to 38% of crashes between motor vehicles and cyclists involve overtaking and close passes, contributing to a fear of cycling for both current and potential riders. Consequently, most research has focused on the cyclist's perceptions of risk in passing events; but the driver's perceptions may be more influential determinants of passing distances and thus, objective crash risk.

Method: In an online cross-sectional survey, participants viewed 24 video clips of naturalistic passing events (external view akin to being a following driver) on urban roads in Queensland, Australia and judged distance and safety for both the portrayed cyclist and the passing driver.

View Article and Find Full Text PDF

The growth in the gig economy and a preference for home delivery of meals due to COVID-19 have led to huge growth in the food delivery business internationally and consequent road safety concerns. There is increasing evidence that delivery riding is an occupation with significant road safety risks because work pressures encourage risky behaviours. However, there is little or no research that directly compares delivery and private riders.

View Article and Find Full Text PDF

Glycogen synthase kinase-3 (GSK3) mediates phosphorylation of several hundred proteins, and its aberrant activity is associated with an array of prevalent disorders. The two paralogs, GSK3α and GSK3β, are expressed ubiquitously and fulfill common as well as unique tasks throughout the body. In the CNS, it is established that GSK3 is involved in synaptic plasticity.

View Article and Find Full Text PDF

Alcohol is a global risk factor for road trauma. Although drink driving has received most of the scholarly attention, there is growing evidence of the risks of alcohol-impaired walking. Alcohol-impaired pedestrians are over-represented in fatal crashes compared to non-impaired pedestrians.

View Article and Find Full Text PDF
Article Synopsis
  • Glycogen synthase kinase 3 (GSK3) inhibits myogenic differentiation and myoblast fusion by blocking the Wnt/β-catenin signaling pathway; lithium can reduce GSK3 activity.
  • In this study, a low dose of lithium (0.5 mM) was shown to enhance myoblast fusion and differentiation in muscle cells, which is significant for muscle health.
  • Treatment with 0.5 mM lithium resulted in increased phosphorylation of GSK3, reduced GSK3 activity by 86%, and higher levels of myogenic markers, indicating its potential therapeutic effects for muscle-related disorders.
View Article and Find Full Text PDF