Publications by authors named "E Roets"
Article Synopsis
- Aberrant embryo implantation and placentation can lead to serious pregnancy complications like preeclampsia, and current risk identification methods are not very accurate.
- The ExPECT study aims to validate a cell-free DNA methylation strategy to diagnose preeclampsia early and identify high-risk pregnancies by analyzing blood samples over time.
- Results showed distinct methylation patterns between healthy and affected pregnancies, with significant differences detectable as early as 12 weeks, leading to the development of promising classification models for diagnosis and prediction.
Article Synopsis
- - Twin pregnancies have a higher risk of complications like fetal growth restriction and twin-to-twin transfusion syndrome (TTTS), which can affect the fetal heart's hemodynamics.
- - This paper reviews existing literature on fetal cardiac function in twin pregnancies using two-dimensional speckle tracking echocardiography (2D STE), finding significant differences in heart strain between donor and recipient twins.
- - Although 2D STE proved feasible for studying monochorionic diamniotic (MCDA) twins, inconsistent results due to varying methodologies indicate a need for further research on its use in uncomplicated twin pregnancies.
Background: Typically, researchers and clinicians determine the agenda in sarcoma research. However, patient involvement can have a meaningful impact on research. Therefore, the Patient-Powered Research Network (PPRN) of the Sarcoma Patient Advocacy Global Network (SPAGN) set up a Priority Setting Partnership (PSP).
View Article and Find Full Text PDFBackground: Sunitinib is an oral anticancer drug approved for the treatment of among others gastrointestinal stromal tumor (GIST). Previous analyses demonstrated an exposure-response relationship at the standard dose, and minimum target levels of drug exposure have been defined above which better treatment outcomes are observed. Therapeutic drug monitoring (TDM) could be used as a tool to optimize the individual dose, aiming at sunitinib trough concentrations ≥37.
View Article and Find Full Text PDFBackground: This systematic review evaluates reporting of patient-reported outcomes (PROs) within randomized clinical trials (RCTs) for advanced soft tissue sarcoma (STS) patients.
Methods: A systematic literature search from January 2000 - August 2022 was conducted for phase II/III RCTs evaluating systemic treatments in adult patients with advanced STS. Quality of PRO reporting was assessed using the CONSORT PRO extension.