Publications by authors named "E Rodriguez Merino"
Background: The loss of finger control in individuals with neuromuscular disorders significantly impacts their quality of life. Electroencephalography (EEG)-based brain-computer interfaces that actuate neuroprostheses directly via decoded motor intentions can help restore lost finger mobility. However, the extent to which finger movements exhibit distinct and decodable EEG correlates remains unresolved.
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- Escherichia coli JU15 is engineered to efficiently produce D-lactic acid from C5 and C6 sugars at 37 °C, but requires strains that can grow near 50 °C for optimal enzyme activity in lignocellulosic biomass processing.
- The new strain GT48 was developed through adaptive evolution to thrive at temperatures up to 48 °C, successfully fermenting glucose to D-lactate at 47 °C with optimal pH at 6.3.
- GT48 outperformed the original strain by producing D-lactate at significantly higher levels (over 1.4 times better) when used in a simultaneous saccharification and fermentation process without needing a pre-saccharification stage.
A copper-catalyzed intramolecular synthesis of 3-alkenyl-2-indazoles from 2-alkynylazobenzenes is described. The reaction proceeds in a single step via C-N bond formation and a subsequent 1,2-hydride shift, affording products in high yields. DFT calculations suggest the 1,2-hydride shift as the rate-determining step.
View Article and Find Full Text PDFThe development of parasite resistance to both artemisinin derivatives and their partner drugs jeopardizes the effectiveness of the artemisinin combination therapy. Thus, the discovery of new antimalarial drugs, with new mechanisms of action, is urgently needed. We recently disclosed that β-carboline was orally efficacious in -infected mice and that it showed low cross-resistance between susceptible and four different drug-resistant strains.
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