Carbohydrate-mediated interactions between chloroviruses and the immune system.

Understanding the molecular mechanisms which drive and modulate host-pathogen interactions are essential when designing effective therapeutic and diagnostic approaches aimed at controlling infectious diseases. Certain large and giant viruses have recently been discovered as components of the human virome, yet little is known about their interactions with the host immune system. We have dissected the role of viral N-linked glycans during the interaction between the glycoproteins from six chloroviruses (belonging to three chlorovirus classes: NC64A, SAG, and Osy viruses) and the representative carbohydrate-binding receptors of the innate immune system.

Improvements in quality of life of patients with multiple sclerosis receiving alemtuzumab in clinical practice: the LEMVIDA study.

Background: Alemtuzumab is a humanized monoclonal antibody approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Its efficacy and safety have been widely demonstrated in clinical trials, but experience from real-world cohorts is also needed to support its clinical use. Quality of life (QoL) outcomes are an important complement to the clinical benefits of treatment, offering a patient-centered perspective on how the drug contributes to general well-being.

Computational and experimental data for undoped and Er-doped lithium tantalate nanofluorescent probes.

The density functional theory (DFT) and experimental data presented in this paper refer to the research article "Computational and experimental study on undoped and Er-doped lithium tantalate nano fluorescent probes". The DFT data contain electronic and optical properties for both LiTaO and LiTaO:Er, with Er occupying either Li or Ta sites at 4.167 mol.

Self-Healing of Microcracks and Scratches in a Carbon-Fiber Reinforced Epoxy Vitrimer by Conventional or Remote Heating.

This study addresses the extension of the service life of carbon-fiber reinforced epoxies by inducing thermal healing of microcracks through the use of a vitrimer as a polymeric matrix. Our aim was to explore the feasibility of using a blend of selected carboxylic acids (citric, glutaric, and sebacic acids) and commercial monomers to design a matrix specifically developed for technological implementation in composites with the ability of intrinsic repair of microcracks under moderate (even remote) heating treatments. The selection of the formulation (the acid blend, catalysts, and monomers) was the result of an exhaustive prescreening analysis of processing requisites and final properties.

Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in natural populations.

Mitochondrial function depends on the effective interactions between proteins and RNA encoded by the mitochondrial and nuclear genomes. Evidence suggests that both genomes respond to thermal selection and promote adaptation. However, the contribution of their epistatic interactions to life history phenotypes in the wild remains elusive.