Efficacy of [Lu]Lu-DOTATATE in metastatic neuroendocrine neoplasms of different locations: data from the SEPTRALU study.

Background: Peptide receptor radionuclide therapy (PRRT) is one of the most promising therapeutic strategies in neuroendocrine neoplasms (NENs). Nevertheless, its role in certain tumor sites remains unclear. This study sought to elucidate the efficacy and safety of [Lu]Lu-DOTATATE in NENs with different locations and evaluate the effect of the tumor origin, bearing in mind other prognostic variables.

Dependency of the remnant I-NaI biokinetics on the administered activity in patients with differentiated thyroid cancer.

Purpose: To study the dependency of the effective half-life on the administered activity and the correlation between the time-integrated activity and the remnant uptake at 2d and 7d in patients treated for DTC with 1.11 GBq, 3.7 GBq or 5.

A retrospective study on the potential of Tc-HDP imaging before therapy for individualizing treatments with Ra-Cl for metastatic castration resistant prostate cancer.

Purpose: Research on dose-effect correlation is necessary to move toward an individualization of treatments of metastatic castration resistant prostate cancer (mCRPC) with Ra-Cl . We first looked for a possible correlation of Tc-HDP lesion uptake in pretreatment whole-body scans (WBSs) with lesion absorbed dose. Moreover, we looked for a possible correlation of Tc-HDP lesion uptake in pretreatment WBSs and of lesion absorbed dose with relative change in the Tc-HDP lesion uptake obtained from pre- and post-treatment WBSs in patients treated for mCRPC with six cycles of Ra-Cl .

Microdosimetry-based determination of tumour control probability curves for treatments with Ac-PSMA of metastatic castration resistant prostate cancer.

We performed Monte Carlo simulations in order to determine, by means of microdosimetry calculations, tumour control probability (TCP) curves for treatments with Ac-PSMA of metastatic castration resistant prostate cancer (mCRPC). Realistic values of cell radiosensitivity, nucleus size and lesion size were used for calculations. As the cell radiosensitivity decreased, the nucleus size decreased and the lesion size increased, the absorbed dose to reach a given TCP increased.

Feasibility and limitations of quantitative SPECT for Ra.

The aim of this paper is to investigate the feasibility and limitations of activity-concentration estimation for Ra using SPECT. Phantom measurements are performed using spheres (volumes 5.5 mL to 26.