Publications by authors named "E Roddy"
Article Synopsis
- - Gout is a chronic condition caused by the immune system's reaction to monosodium urate crystals due to high uric acid levels, and recent research sheds light on its inflammatory mechanisms.
- - A large genome-wide association study (GWAS) involving 2.6 million people identified 377 genetic locations linked to gout, with a focus on 149 new loci related to urate and gout inflammation.
- - The study also pinpointed candidate genes influencing the inflammatory response in gout, including those affecting NLRP3 inflammasome activity, and suggests a potential causal role of specific genetic factors in developing the disease.
J Orthop Trauma
September 2024
Article Synopsis
- This study evaluated modified Radiographic Union Scale for Tibia (mRUST) scores over time in patients with distal femur fractures treated with intramedullary nails, to identify factors influencing healing and possible reoperation.
- Conducted in ten Level I Trauma Centers, the research included 155 fractures from 152 patients, focusing on mRUST scores at 3, 6, and 12 months post-surgery, with the primary goal of finding predictors for union timing.
- Results showed that a 3-month mRUST score of ≤8 indicated a higher chance of reoperation, and factors such as tobacco use and open fractures correlated with delayed healing times.
Article Synopsis
- Intimate partner violence (IPV) is a common issue in the U.S., with orthopedic surgeons able to identify injuries related to IPV, since musculoskeletal injuries are frequently seen in victims.*
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- A systematic review analyzed 316 articles and included 16 studies, confirming that upper extremity fractures, particularly minimally displaced phalangeal fractures, are the most common injuries linked to IPV.*
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- The study provides valuable insights for physicians to recognize IPV through injury patterns, highlighting a need for more research on the topic due to the ongoing prevalence of IPV.*
Ann Intern Med
September 2024
Article Synopsis
- A study investigated the potential benefits of methotrexate, an antirheumatic drug, in treating knee osteoarthritis (KOA) pain through a multicenter, double-blind, placebo-controlled trial involving 207 participants.
- Participants were randomly assigned to receive either methotrexate or a placebo for 12 months while continuing their usual pain relief medications, with a primary focus on assessing average knee pain at 6 months.
- Results indicated that the methotrexate group experienced a significant decrease in knee pain compared to the placebo group, suggesting methotrexate may provide symptomatic relief for KOA.
