A novel way to integrate economic information into clinical practice guidelines.

Background: Clinical guidelines are widely used to support clinical decision making, so they could also provide economic information about medical interventions to promote cost-conscious health care. We developed a new way to integrate economic information into the Finnish Current Care Guidelines.

Methods: Our development team consisted of clinical guideline specialists and health economists.

Cost-Effectiveness of Digital Preventive Parent Training for Early Childhood Disruptive Behaviour.

Background: Childhood disruptive behaviour disorder associates with various, also costly problems. Parent training is effective in reducing childhood disruptive behaviour. Only a few studies have evaluated the cost-effectiveness of digital parent training in reducing children's disruptive behaviour.

Improving the implementation of KiVa antibullying program with tailored support: Study protocol for a cluster randomized controlled trial.

Background: There are no evidence-based models to support the implementation of school-based bullying prevention programs. Our primary objective is to examine the impact of tailored support on the implementation of the KiVa antibullying program. Our second objective is to evaluate whether the offered support influences student outcomes (e.

Adenosine A receptor availability in cerebral gray and white matter of patients with Parkinson's disease.

Objective: Atrophic changes in cerebral gray matter of patients with PD have been reported extensively. There is evidence suggesting an association between cortical gyrification changes and white matter abnormalities. Adenosine A receptors have been shown to be upregulated in cerebral white matter and on reactive astrocytes in preclinical models of neurodegenerative diseases.