Publications by authors named "E Richling"
Article Synopsis
- - In in vitro toxicology testing, results often rely on nominal concentrations, which might not accurately reflect the actual levels of a substance due to its physical properties and the assay setup, potentially leading to false negatives regarding toxicity.
- - This study focused on three natural terpenes that are considered low toxicity: (R)-(+)-limonene (RLIM), β-myrcene (βMYR), and linalool (LIN), which face testing challenges due to their hydrophobicity and volatility.
- - By using a specialized incubation method that reduces losses from volatilization and sorption, the researchers found that while the terpenes showed cytotoxic effects at low doses, they did not demonstrate mutagenicity in the
Reactivity of the 2-Methylfuran Phase I Metabolite 3-Acetylacrolein Toward DNA.
J Agric Food Chem
November 2024
2-Methylfuran (2-MF) is a well-known industrial chemical and also formed via thermal treatment of food. One main source of 2-MF in the human diet is coffee. 2-MF is known to form 3-acetylacrolein (AcA, 4-oxopent-2-enal) via cytochrome P 450 metabolism and further reacts with amino acids in vivo.
View Article and Find Full Text PDF2-Methylfuran (2-MF) is a process-related contaminant found primarily in heat-treated foods, such as coffee or canned food. The oxidative metabolic activation of 2-MF is supposed to follow the pathway established for furan, which is known to generate the highly reactive metabolite butenedial (BDA). In the case of 2-MF, generation of the BDA homologue 3-acetylacrolein (AcA) is to be expected.
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- The study examines how light exposure, specifically from a UV-C source, affects the formation of 2-aminoacetophenone from tryptophan in wine, influenced by oxygen levels and transition metals.
- More light exposure and higher oxygen concentrations led to increased levels of 2-aminoacetophenone, while transition metals slowed its formation and indicated a competing reaction involving acetaldehyde.
- The research highlights the importance of oxygen, not only in the degradation of riboflavin but also in enhancing the light-induced formation of 2-aminoacetophenone, providing new insights into riboflavin's role in these reactions.
Increased intake of dietary antioxidants such as anthocyanins, which are enriched in colourful fruits, is a promising alternative to reduce the risk of degenerative diseases such as Alzheimer's Disease (AD). Since Amyloid β (Aβ) is one of the key components contributing to AD pathology, probably by reactive oxygen species (ROS) induction, this study investigated the preventive effect of anthocyanin-rich bilberry extract (BE) and its anthocyanin fraction (ACN) on ROS generation and cell toxicity. The results showed a significant and concentration-dependent decrease in neuroblastoma cell (SH-SY5Y) viability by BE or ACN, whereas no cell toxicity was observed in HeLa cells.
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