The influence of thermal and hypoxia induced habitat compression on walleye (Sander vitreus) movements in a temperate lake.

Background: Globally, temperate lakes are experiencing increases in surface water temperatures, extended periods of summer stratification, and decreases of both surface and deep water dissolved oxygen (DO). The distribution of fish is influenced by a variety of factors, but water temperature and dissolved oxygen are known to be particularly constraining such that with climate change, fish will likely feel the "squeeze" from above and below.

Methods: This study used acoustic telemetry to explore the effects of both thermal stratification and the deoxygenation of the hypolimnion on walleye (Sander vitreus) movements in a coastal embayment in Lake Ontario.

A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques.

Ebola virus (EBOV) causes severe disease in humans, with mortality as high as 90%. The small-molecule antiviral drug remdesivir (RDV) has demonstrated a survival benefit in EBOV-exposed rhesus macaques. Here, we characterize the efficacy of multiple intravenous RDV dosing regimens on survival of rhesus macaques 42 days after intramuscular EBOV exposure.

Genomic Surveillance of Foodborne Pathogens: Advances and Obstacles.

Context: The genomic surveillance of foodborne pathogens in the United States has grown exponentially in the past decade, grounded in a powerful combination of novel sequencing technologies, bioinformatic approaches, data-sharing networks, and metadata harmonization efforts. This practice report examines recent advances in genomic epidemiology as applied to food safety programs and delineates State, Tribal, Local, and Territorial infrastructure necessary for continued life-saving improvements in public health.

Program: National databases of foodborne pathogen genomes, along with data sharing and evaluation networks such as GenomeTrakr and PulseNet, have transformed how connections are made among isolates and how root causes of outbreaks are determined, allowing much more timely interventions to protect public health.