A Multicenter Phase 1 Trial Evaluating Nanoliposomal Irinotecan for Heated Intraperitoneal Chemotherapy Combined with Cytoreductive Surgery for Patients with Peritoneal Surface Disease.

Background: Nanoliposomal irinotecan (nal-IRI) is a promising novel hyperthermic intraperitoneal chemotherapy (HIPEC) agent given its enhanced efficacy against gastrointestinal tumors, safety profile, thermo-synergy, and heat stability. This report describes the first in-human phase 1 clinical trial of nal-IRI during cytoreductive surgery (CRS) and HIPEC.

Methods: Patients with peritoneal surface disease (PSD) from appendiceal and colorectal neoplasms were enrolled in a 3 + 3 dose-escalation trial using nal-IRI (70-280 mg/m) during HIPEC for 30 min at 41 ± 1 °C.

Formation of phenylacetylene and benzocyclobutadiene in the -benzyne + acetylene reaction.

-benzyne is a potentially important precursor for polycyclic aromatic hydrocarbon formation, but much is still unknown about its chemistry. In this work, we report on a combined experimental and theoretical study of the -benzyne + acetylene reaction and employ double imaging threshold photoelectron photoion coincidence spectroscopy to investigate the reaction products with isomer specificity. Based on photoion mass-selected threshold photoelectron spectra, Franck-Condon simulations, and ionization cross section calculations, we conclude that phenylacetylene and benzocyclobutadiene (PA : BCBdiene) are formed at a non-equilibrium ratio of 2 : 1, respectively, in a pyrolysis microreactor at a temperature of 1050 K and a pressure of ∼20 mbar.

Femtosecond dynamics of diphenylpropynylidene in ethanol and dichloromethane.

Carbon chains with an odd number of C atoms are reactive intermediates with a high biradical character. Here we report a joint experimental and computational investigation of the dynamics of diphenylpropynylidene, CH-C-CH, in dichloromethane and ethanol. The biradical is generated by ultraviolet light from 1,3-diphenyldiazopropyne.

Kinetics of 1- and 2-methylallyl + O reaction, investigated by photoionisation using synchrotron radiation.

The reaction kinetics of the isomers of the methylallyl radical with molecular oxygen has been studied in a flow tube reactor at the vacuum ultraviolet (VUV) beamline of the Swiss Light Source storage ring. The radicals were generated by direct photodissociation of bromides or iodides at 213 nm. Experiments were conducted at room temperature and low pressures between 1 and 3 mbar using He as the buffer gas.

Methylbismuth: an organometallic bismuthinidene biradical.

We report the generation, spectroscopic characterization, and computational analysis of the first free (non-stabilized) organometallic bismuthinidene, BiMe. The title compound was generated from BiMe by controlled homolytic Bi-C bond cleavage in the gas phase. Its electronic structure was characterized by a combination of photoion mass-selected threshold photoelectron spectroscopy and DFT as well as multi-reference computations.