"Someday, I'll be an ancestor:" Understanding indigenous intergenerational connectedness through qualitative research to inform measure development.

Intergenerational connectedness broadly encompasses relations among humans, lands, and all living and spiritual beings, and functions as an important part of Indigenous well-being. Many public health campaigns and interventions aim to promote connectedness to support holistic wellness and reduce health inequities. Currently, however, there are no measurement tools to assess intergenerational connectedness to support culturally grounded research and program evaluation.

DLK1 distinguishes subsets of NF1-associated malignant peripheral nerve sheath tumors with divergent molecular signatures.

Purpose: MPNST is the leading cause of premature death among individuals with NF1 and the transcriptional aberrations that precede malignant transformation and contribute to MPNST tumorigenesis remain poorly defined. Alterations involving CDKN2A and components of PRC2 have been implicated as early drivers of PNST evolution, but these events do not occur in all MPNST. Accordingly, emerging data has begun to highlight the importance of molecular-based stratification to improve outcomes in patients with NF1-PNST.

Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia.

Unlabelled: Macroautophagy (autophagy hereafter) captures intracellular components and delivers them to lysosomes for degradation and recycling . In adult mice, autophagy sustains metabolism to prevent wasting by cachexia and to survive fasting, and also suppresses inflammation, liver steatosis, neurodegeneration, and lethality . Defects in autophagy contribute to metabolic, inflammatory and degenerative diseases, however, the specific mechanisms involved were unclear .

Comparison of interstitial lung disease diagnoses in urban and rural areas among participants in the pulmonary fibrosis foundation patient registry.

Unlabelled: Little is known about differences in interstitial lung disease (ILD) diagnosis by geographic location. The aim of this study is to evaluate differences in cross-sectional ILD diagnosis between patients in urban and rural areas.

Methods: This is a retrospective analysis of participants (n = 1992) in the Pulmonary Fibrosis Foundation (PFF) Patient Registry.

Fostering Ubuntu in Black Adolescents: Group Counseling as a Pathway to Advocacy.

Using the philosophy of Ubuntu (I am because we are), a grant-funded group for African American, inner-city youth between the ages of 14 and 18 was implemented and studied. Five group members participated in the six-week blended model group intervention that culminated in an agreed-upon social justice project. During sessions, participants discussed issues in five main areas: school, home, community, friendships, and internal issues.