Publications by authors named "E R Simonetti"
Introduction: Reactivation of thymopoiesis in adult patients with autoimmune disorders treated with autologous haematopoietic stem cell transplantation (AHSCT) is supported by studies exploring immunoreconstitution. Radiological evidence of thymic hyperplasia after AHSCT was previously reported in patients with systemic sclerosis, but, to our knowledge, it has not been described in multiple sclerosis (MS), where premature thymic involution has been observed and immunosenescence might be accelerated by disease-modifying treatments (DMTs).
Participants And Methods: monocentric case series including MS patients who performed a chest CT scan for clinical purposes after having received AHSCT (BEAM/ATG regimen) for aggressive MS failing DMTs.
Background: Bordetella pertussis continues to cause whooping cough globally even in countries with high immunisation coverage. Booster vaccinations with acellular pertussis vaccines are thus used in children, adolescents, and adults. T cell immunity is crucial for orchestrating the immune response after vaccination.
View Article and Find Full Text PDFArticle Synopsis
- Immune-checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with immune-mediated pneumonitis (im-PN) being a rare but serious complication that requires prompt diagnosis and management to prevent severe outcomes and allow for continued cancer treatment.
- A study collected data from 1004 cancer patients treated with ICIs, finding that 24 (2%) developed im-PN, with varying degrees of severity; most patients responded well to steroid treatment, leading to recovery in 21 individuals within an average of 14 weeks.
- Three main radiologic patterns of im-PN were identified (organizational pneumonia-like, pulmonary eosinophilia, and hypersensitivity pneumonitis), and bronchoalve
Introduction: Extraskeletal Ewing sarcoma (EEwS) is a rare malignant tumor, and current international recommendations indicate systemic and local treatment like bone Ewing sarcoma (BEwS); to the best of our knowledge, very few studies tried to explore the clinical and genetic characteristics of this tumor, and the most appropriate treatment strategy remains uncertain.
Methods: We reviewed 35 EEwS cases enrolled at Rizzoli Orthopedic Institute in Bologna, Italy, between 1988-2022. We performed RNA sequencing in 18 Ewing sarcoma cases, including 12 BEwSs and 6 EEwSs.
Objectives: We explored the role of metabolic hormones and the B-cell repertoire in the association between nutritional status and vaccine responses.
Methods: In this prospective cohort study, nested within a larger randomized open-label trial, 211 South African children received two doses of measles vaccine and two or three doses of pneumococcal conjugate vaccine (PCV). Metabolic markers (leptin, ghrelin and adiponectin) and distribution of B-cell subsets (n = 106) were assessed at 18 months of age.