Publications by authors named "E R Segura"

From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.

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IL1-β plays a central role in inflammation but its biological action needs to be tightly controlled. Such negative regulation can be exerted by the decoy receptor IL1R2. However, IL1R2 biology in immune cells remains poorly characterized, in particular in monocytes.

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Our group has developed a new nitinol endoluminal self-expandable device for microvascular anastomosis. It attaches to each vessel ending with opposite directed microspikes and reaches complete expansion at body temperature, using the nitinol shape memory capacity. The main purpose of this first in vivo trial is to evaluate the mechanical viability of the device and its immediate and early functionality.

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Article Synopsis
  • Cytokines like IL-4 activate immune cell responses by triggering transcription factors, specifically STAT6, which affects cellular functions and metabolism.* -
  • The aryl hydrocarbon receptor (AhR) plays a regulatory role by enhancing certain IL-4 responses and inhibiting the metabolic shift towards fatty acid β-oxidation.* -
  • AhR influences the activity of SHP-1, extending STAT6's effect on target genes, suggesting that AhR's role in this process may operate through a nongenomic mechanism.*
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Objective: Many stroke survivors still present with upper-limb paresis six months post-stroke, impacting their autonomy and quality of life (QoL). We designed an enriched Music-supported Therapy (eMST) program to reduce disability in this population. We evaluated the eMST's effectiveness in improving functional abilities and QoL in chronic stroke individuals compared to the conventional motor program Graded Repetitive Arm Supplementary Program (GRASP).

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