Publications by authors named "E R Parise"
Humans categorize objects not only based on perceptual features (e.g. red, rounded), but also function (e.
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- Astrocytes in the nucleus accumbens (NAc) have been shown to play a significant role in stress and depression, but their transcriptional responses to stress were not well understood prior to this study.
- Using methods like RNA-sequencing and immunohistochemistry, researchers investigated how chronic social defeat stress (CSDS) affects the transcriptome of NAc astrocytes in male mice.
- The findings revealed a strong transcriptional response in astrocytes linked to CREB activation, which influences whether a mouse becomes stress-resilient or stress-susceptible, highlighting the potential of astrocytes in understanding neuropsychiatric disorders.
Histone post-translational modifications are critical for mediating persistent alterations in gene expression. By combining unbiased proteomics profiling and genome-wide approaches, we uncovered a role for mono-methylation of lysine 27 at histone H3 (H3K27me1) in the enduring effects of stress. Specifically, mice susceptible to early life stress (ELS) or chronic social defeat stress (CSDS) displayed increased H3K27me1 enrichment in the nucleus accumbens (NAc), a key brain-reward region.
View Article and Find Full Text PDFWhen infants start mastering their first language, they may start to notice when words are used incorrectly. Around 14-months of age, infants detect incorrect labeling when they are presented with an object which is labeled while still visible. However, things that are referred to are often out of sight when we communicate about them.
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- Major depressive disorder (MDD) is associated with changes in brain structure and synaptic function, particularly in limbic regions.
- Astrocytes, brain cells affected by chronic stress, show altered gene profiles that may play a role in these changes, especially in the nucleus accumbens (NAc).
- The study found that a specific astrocyte-produced protease gene is downregulated in males and upregulated in females, revealing sex-specific responses to stress and offering potential new targets for MDD treatment.