The role of macrophages in the tissues regeneration stimulated by the biomaterials.

Allogenic grafted tissues are subjected to biodegradation and replaced by the regenerate. To minimize the immune response and improve the rebuilding of tissues there was developed a technology to treat tissues with a cells elimination and dosed out extraction of proteoglycanes (Alloplant. With aim to clarify the role of macrophages in the tissues regeneration resulting implantation the biomaterials 112 rats were injected the allogenic and xenogenic (rabbit's) pulverized biomaterials in the form of suspension.

[Cosmetic results of posttraumatic eyeball subatrophy surgical treatment using "alloplant" biomaterials with subsequent use of prostheses].

A complex of surgical operations making use of Alloplant biomaterials, performed in 47 patients with initial posttraumatic subatrophy and 79 patients with well-developed and far advanced stages of this condition, helped preserve the eye as anatomical organ in 97.5% patients, with enlargement of the eyeball in two-thirds of patients and stabilization in one-third. Optic reconstructive operations were later performed and visual acuity improved in patients with the initial stage of subatrophy.

[Effects of repeated courses of electrostimulation and psychophysiologic correction on visual system characteristics in patients with poor vision of different genesis].

The effect of 5 courses of transcutaneous electrostimulation and of a combination of electrostimulation and psychophysiological correction of vision on the visual functions is assessed in 47 patients (90 eyes) with poor sigh of different genesis. Courses of 8-10-days were administered twice a year for 2.5-3 years.

Basic research conducted on alloplant biomaterials.

Purpose: To reduce antigenicity of allografts and stimulate their replacement by natural recipient tissues.

Methods: Experimental allotransplantation of different tissues (fascias, tendons, derma, fat, etc.) with histological, histochemical, electron microscopical, electron histochemical examination 3, 5, 7, 14, 21, 30, 60, 120, 180 and 360 days postoperatively.

[Surgical treatment of eyeball atrophy with biological implant material alloplant: the structure and time course of morphological and physiological changes].

The time course of changes in the size of the eyeball and in intraocular pressure (IOP) is analyzed in 50 patients with posttraumatic subatrophy of the eyeball subjected to surgical treatment making use of the Alloplant biological materials and followed up for at least 3 years. The methods of dispersion, factor, cluster, and discriminant analysis have been used. The phases of the initial (directly after surgery) and remote changes were distinguished; changes in the size of the eyeball virtually did not depend on changes in IOP.