Publications by authors named "E R LENG"
We report the diagnosis, treatment, and outcomes of a 52-year-old woman who originally presented to her primary care provider with adenopathy. Core needle biopsy (CNB) was inconclusive as it could not distinguish between follicular and diffuse large B-cell lymphomas (DLBCLs). A left axillary surgical lymph node biopsy was performed and demonstrated that the patient had a DLBCL arising from grade 3 follicular lymphoma.
View Article and Find Full Text PDFObjective: The utility of metagenomic next-generation sequencing (mNGS) in the diagnosis of tuberculous meningitis (TBM) remains uncertain. We performed a meta-analysis to comprehensively evaluate its diagnostic accuracy for the early diagnosis of TBM.
Methods: English (PubMed, Medline, Web of Science, Cochrane Library, and Embase) and Chinese (CNKI, Wanfang, and CBM) databases were searched for relevant studies assessing the diagnostic accuracy of mNGS for TBM.
Article Synopsis
- Tuberculous meningitis (TBM) is the leading form of central nervous system tuberculosis, associated with high rates of mortality and disability, making early diagnosis crucial for improving patient outcomes.
- The traditional diagnostic methods for TBM, which include microscopy, culture, and PCR, are often ineffective due to the low bacterial load in the cerebrospinal fluid (CSF) and the limitations of conventional techniques.
- This review highlights the current landscape of TBM diagnostics, emphasizing ongoing research, the pros and cons of available methods, and the challenges clinicians face in ensuring accurate and efficient diagnosis.
The trade-off effect between strength and fracture toughness typically observed in composites is challenging for the design and development of novel materials. An amorphous state can impede the trade-off effect of strength and fracture toughness, improving the mechanical properties of composites. Choosing the typical tungsten carbide-cobalt (WC-Co) cemented carbides as examples, where the amorphous binder phase was found, the impact of binder phase Co on the mechanical properties was further investigated by molecular dynamics (MD) simulations.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on tuberculous meningitis (TBM) in South China, particularly looking at the occurrence of cranial nerve palsy as a serious complication in these patients.
- Out of 114 patients analyzed, about 33.3% experienced cranial nerve palsy, with the most common types being oculomotor and optic nerve palsies.
- Key risk factors identified for developing cranial nerve palsy included the presence of focal neurological deficits, extracranial tuberculosis, and elevated total white cell count in cerebrospinal fluid.