Design, synthesis, and screening of an RNA optimized fluorinated fragment library.

Fragment-based screening is an efficient method for early-stage drug discovery. In this study, we aimed to create a fragment library optimized for producing high hit rates against RNA targets. RNA has historically been an underexplored target, but recent research suggests potential for optimizing small molecule libraries for RNA binding.

Photoswitching Molecules Functionalized with Optical Cycling Centers Provide a Novel Platform for Studying Chemical Transformations in Ultracold Molecules.

A novel molecular structure that bridges the fields of molecular optical cycling and molecular photoswitching is presented. It is based on a photoswitching molecule azobenzene functionalized with one and two CaO- groups, which can act as optical cycling centers (OCCs). This paper characterizes the electronic structure of the resulting model systems, focusing on three questions: (1) how the electronic states of the photoswitch are impacted by a functionalization with an OCC; (2) how the states of the OCC are impacted by the scaffold of the photoswitch; and (3) whether the OCC can serve as a spectroscopic probe of isomerization.

7 days of L-citrulline supplementation does not improve running performance in the heat whilst in a hypohydrated state.

Purpose: 7 days L-citrulline supplementation has been reported to improve blood pressure, O kinetics, gastrointestinal (GI) perfusion and endurance cycling performance through increasing arterial blood flow. In situations where blood volume is compromised (e.g.

ThF thin films for solid-state nuclear clocks.

After nearly 50 years of searching, the vacuum ultraviolet Th nuclear isomeric transition has recently been directly laser excited and measured with high spectroscopic precision. Nuclear clocks based on this transition are expected to be more robust than and may outperform current optical atomic clocks. These clocks also promise sensitive tests for new physics beyond the standard model.