Ectodermal dysplasias (ED) are disorders that affect ectodermal-derived tissues during embryonic development. These disorders occur when the ectoderm, the outermost layer of embryonic tissue does not develop normally. Patients present abnormalities of two or more ectoderm-derived structures and the clinical presentation can vary greatly depending on the type a patient has.
View Article and Find Full Text PDFBackground: Previous studies identified racial differences in core clinical clerkship evaluations and components of residency applications, including the medical school performance evaluation and standard letter of evaluation. However, there are no studies that have examined grading differences in the emergency medicine (EM) clerkship. Our goal was to determine whether there are differences in EM clerkship grades and its components (National Board of Medical Examiners [NBME] exam scores and clinical assessments) between underrepresented in medicine (URiM) and non-URiM students.
View Article and Find Full Text PDFBackground: Structural disparities in the United States (U.S.) healthcare system negatively impact care access and quality for racial and ethnic minorities.
View Article and Find Full Text PDFInt J Pediatr Otorhinolaryngol
January 2025
Objective: To present our experience with off-label MED-EL Bonebridge implantation in pediatric patients younger than 12 years of age and compare outcomes to pediatric patients 12 years and older.
Methods: Pediatric patients who underwent Bonebridge implantation were included in a retrospective cohort study and were categorized by off-label use (<12 years) and ≥12 years at time of bone conduction implantation (BCI). Hearing outcomes were collected after implant activation, which was typically 4-8 weeks post-implantation.
Colorectal cancer encompasses a heterogeneous group of malignancies that differ in pathophysiological mechanisms, immune response and infiltration, therapeutic response, and clinical prognosis. Numerous studies have highlighted the clinical relevance of tumor-infiltrating immune cells among different types of colorectal tumors yet vary in cell type definitions and cell identification strategies. The distinction of immune signatures is particularly challenging when several immune subtypes are involved but crucial to identify novel intercellular mechanisms within the tumor microenvironment.
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