Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade.

Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer's disease and neurodegeneration. Here, we examine its associations with up to over a decade-long changes in brain atrophy and microstructure. Higher in vivo skeletal muscle oxidative capacity via MR spectroscopy (post-exercise recovery rate, k) is associated with less ventricular enlargement and brain aging progression, and less atrophy in specific regions, notably primary sensorimotor cortex, temporal white and gray matter, thalamus, occipital areas, cingulate cortex, and cerebellum white matter.

Providing healthcare under the threat of gang-violence: a survey of Haitian healthcare providers.

In addition to having some of the worst health outcomes in the region, Haiti faces a political and economic crisis. The most recent humanitarian crisis includes an increase in homicides and kidnappings in the capital Port-au-Prince. This study is a cross-sectional, mixed methods online survey of health workers and medical students in Port-au-Prince from May 20 - September 15, 2023.

Benefits of an online group dance program for adolescents' social bonding and wellbeing.

Introduction: The Covid-19 pandemic and its ensuing effects on mental health made it clearer than ever that social bonds are critical for survival, flourishing, and mental wellbeing. Experimental laboratory-based research with children and adults shows that activities involving movement alignment and joint action, such as dance, can facilitate social bonds.

Methods: This study examined whether an online group dance intervention positively affects social bonding and wellbeing using a randomized control design.

Shared plasma metabolomic profiles of cognitive and mobility decline predict future dementia.

Experiencing decline in both cognition and mobility is associated with a substantially higher dementia risk than cognitive decline only. Metabolites associated with both cognitive and mobility declines may be early predictors of dementia and reveal specific pathways to dementia. We analyzed data from 2450 participants initially free of dementia who had 613 metabolites measured in plasma in 1998-1999 (mean age = 75.

Plasma metabolomic markers underlying skeletal muscle mitochondrial function relationships with cognition and motor function.

Background: Lower skeletal muscle mitochondrial function is associated with future cognitive impairment and mobility decline, but the biological underpinnings for these associations are unclear. We examined metabolomic markers underlying skeletal muscle mitochondrial function, cognition and motor function.

Methods: We analysed data from 560 participants from the Baltimore Longitudinal Study of Aging (mean age: 68.