Publications by authors named "E R Dorsey"
Background: Huntington's disease, a neurodegenerative disorder, impairs both upper and lower limb function, typically assessed in clinical settings. However, wearable sensors offer the opportunity to monitor real-world data that complements clinical assessments, providing a more comprehensive understanding of disease symptoms.
Methods: In this study, we monitor upper limb function in individuals with Huntington's disease (HD, n = 16), prodromal HD (pHD, n = 7), and controls (CTR, n = 16) using a wrist-worn wearable sensor over a 7-day period.
Background: Longitudinal qualitative data on what matters to people with Parkinson's disease are lacking and needed to guide patient-centered clinical care and development of outcome measures.
Objective: To evaluate change over time in symptoms, impacts, and relevance of digital measures to monitor disease progression in early Parkinson's.
Methods: In-depth, online symptom mapping interviews were conducted with 33 people with early Parkinson's at baseline and 1 year later to evaluate (A) symptoms, (B) impacts, and (C) relevance of digital measures to monitor personally relevant symptoms.
In a prospective, remote natural history study of 277 individuals with (60) and genetically at risk for (217) Parkinson's disease (PD), we examined interest in the return of individual research results (IRRs) and compared characteristics of those who opted for versus against the return of IRRs. Most ( = 180, 65%) requested sharing of IRRs with either a primary care provider, neurologist, or themselves. Among individuals without PD, those who requested sharing of IRRs with a clinician reported more motor symptoms than those who did not request any sharing (mean (SD) 2.
View Article and Find Full Text PDFBackground And Objectives: To identify trends in educational debt for US medical school graduates entering neurology and compare debt to anticipated compensation.
Methods: Data of 148 accredited medical schools were obtained from the Association of American Medical Colleges Graduation and Matriculating Student Questionnaires to identify self-reported educational debt for graduates pursuing neurology training. Trends were assessed in a 2-year interval from 2010 to 2021.
Article Synopsis
- - Huntington's disease (HD) impacts both upper and lower limb function, and this study used a wrist-worn sensor to monitor upper limb movements in daily activities among individuals with HD, prodromal HD (pHD), and healthy controls (CTR) over a week.
- - Participants were highly compliant in wearing the sensor, and the study analyzed goal-directed movements (GDM) using deep learning, finding significant differences in GDM characteristics among the three groups, particularly noting that HD individuals performed fewer long-duration movements compared to CTR.
- - The research successfully used statistical and machine learning models to distinguish between the groups and predict clinical scores, achieving a balanced accuracy of 67%, with certain movement metrics correlating strongly with clinical evaluations