Publications by authors named "E R Doran"
The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable factors, with its molecular etiology still unclear. Here we present a spatial transcriptomic (ST) and single-nucleus transcriptomic survey of late-onset sporadic AD and AD in Down syndrome (DSAD). Studying DSAD provides an opportunity to enhance our understanding of the AD transcriptome, potentially bridging the gap between genetic mouse models and sporadic AD.
View Article and Find Full Text PDFComparing research attitudes in Down syndrome and non-Down syndrome research decision-makers.
Alzheimers Dement (N Y)
July 2024
Article Synopsis
- The study investigates recruitment challenges faced by decision-makers for individuals with and without Down syndrome (DS), emphasizing the need to understand differing research attitudes to avoid sample bias.* ! -
- Using data from two registries, the study compares Research Attitudes Questionnaire (RAQ) scores between non-DS decision-makers and family decision-makers of individuals with DS.* ! -
- Although overall RAQ scores were similar, the study found that DS decision-makers expressed a greater sense of responsibility to help others but were less optimistic about medical research curing major diseases in their lifetime.* !
Importance: The United States Preventive Services Task Force (USPSTF) has considered the topic of prevention of child maltreatment multiple times over its nearly 40-year history, each time reaching the conclusion that the evidence is insufficient to recommend for or against interventions aimed at preventing this important health problem with significant negative sequelae before it occurs. In the most recent evidence review, which was conducted from August 2021 to November 2023 and published in March 2024, the USPSTF considered contextual questions on the evidence for bias in reporting and diagnosis of maltreatment in addition to key questions regarding effectiveness of interventions to prevent child maltreatment.
Observations: A comprehensive literature review found evidence of inaccuracies in risk assessment and racial and ethnic bias in the reporting of child maltreatment and in the evaluation of injuries concerning for maltreatment, such as skull fractures.
Article Synopsis
- * Key findings include her ApoE genotype (E2/3) linked to a lower dementia risk, neuroimaging showing stable amyloid and moderate tau levels, and intermediate Alzheimer’s pathology with added Lewy body and cerebrovascular issues.
- * The study highlights the complex relationship between Alzheimer's symptoms and brain changes in Down syndrome, suggesting the need for more research on factors that contribute to cognitive resilience in this population.
Article Synopsis
- A study investigates the relationship between obstructive sleep apnea (OSA) and insomnia symptoms with Alzheimer's disease (AD) in adults with Down syndrome (DS), highlighting the need for more research in this area.
- Findings show that older women with DS who have dementia experience more severe insomnia symptoms compared to those without dementia, but OSA symptoms do not differ significantly.
- The results suggest that treating insomnia symptoms could be crucial for improving daily living activities and slowing the progression of dementia in adults with DS.