Recombinant human TSH increases the efficacy of a fixed activity of radioiodine for treatment of multinodular goitre.

Context: High doses of (131)I are usually needed in the treatment of multinodular goitre (MNG) for effective thyroid volume (TV) reduction. Recombinant human thyroid-stimulating hormone (rhTSH) is an adjuvant to enhance (131)I uptake, allowing a decrease in radiation activity and enhancing (131)I efficacy.

Objective: To evaluate whether rhTSH increases the efficacy of a fixed activity of (131)I for the treatment of MNG.

[Main causes of low bone mass in premenopausal women referred to a Metabolic Bone Clinic of Curitiba].

We conducted a chart review of premenopausal women with low bone mineral density referred to the Metabolic Bone Clinic of Federal University of Paraná, to determine the outline of these patients regarding their risk factors and secondary causes of osteoporosis. Thirty-four women (19-48 years old) were evaluated. Twenty nine (85.

[Use of lithium carbonate for the treatment of amiodarone-induced thyrotoxicosis].

Among the amiodarone-induced thyroid dysfunctions, thyrotoxicosis is the most troublesome and with the highest rate of morbidity and mortality. Treatment consists in the use of a high dose of anti-thyroid drugs and steroids in an isolated form or in combination. Association of several other drugs have been proposed for the treatment of refractory cases.