Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety.

We report herein the design, synthesis and biological evaluation of series of 7-substituted fluoroquinolones with pyridoxine derivatives. In vitro screening of antibacterial activity and toxicity of 39 synthesized fluoroquinolones defined compounds 7 and 28 as lead compounds for further investigations. On various clinical isolates lead compounds 7 and 28 exhibited antibacterial activity comparable with reference fluoroqinolones.

[A retrospective analysis of the effect of pregnancy on the course of multiple sclerosis].

Aim: For a long time it was believed that pregnancy worsens the clinical course of multiple sclerosis. In several European countries, there have been several studies that have demonstrated remission of autoimmune aggression during pregnancy. We studied the effect of pregnancy on the course of multiple sclerosi.

[The effect of genetic factors on the phenotypic expression of multiple sclerosis].

A total of 326 patients with multiple sclerosis (MS) according to the McDonald criteria (2005) were recruited to the study. Single nucleotide polymorphisms in the CD40 gene (rs6074022, rs1883832, rs1535045 and rs11086998) and the KIF1B gene (rs10492972 and rs3135388) were genotyped using TaqMan technology. We found a significant association of rs1883832 (risk allele T, OR=1.

[Combined therapy of aggressive remitted multiple sclerosis with mitoxantrone in combination with copaxone].

Patients with so called aggressive multiple sclerosis were treated. The course of disease is considered aggressive if there are clinical and tomographic signs of high disease activity with the frequency of exacerbations not less than 3 during 2 years. Nine patients with this course of disease were examined.

[The theory of a low-frequency emitter for ultrasonic therapy].

While performing ultrasonic therapy for some soft tissue diseases, a deep tissue ultrasound penetration should be prevented since there may be potential thermal effects on the borderline surfaces (the periostrium, articular menisci, etc.) with greatly varying acoustic properties. For this, a bimorphic low-wave emitter should be used.