Publications by authors named "E R Brunt"
Article Synopsis
- Liver biopsies have been crucial in understanding the causes and development of acute liver diseases, although their role has evolved with new diagnostic methods.
- While they are not mandatory in clinical guidelines for acute liver failure (ALF) and acute-on-chronic liver failure (ACLF), many medical centers continue to perform them because they are relatively safe and provide important prognostic information.
- The increasing use of liver biopsies for diagnosing less severe acute liver injuries has led to a shift in the types of specimens analyzed, emphasizing the need for histopathologists to be prepared for these complex cases.
Article Synopsis
- The text discusses the challenges of assessing drug-induced liver injury (DILI) in clinical trials for metabolic dysfunction-associated steatohepatitis (MASH) without routine liver biopsies.
- It details the efforts of the Liver Forum, which organized webinars and formed a Histology Working Group to develop consensus documents on the role of liver biopsy in DILI assessment during MASH trials from 2020 to 2022.
- The findings suggest that while liver biopsy is not always definitive, histologic evaluation can provide essential insights that influence patient management, clarify the nature of liver injury, and inform drug development decisions.
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a rare autosomal dominant disease resulting from a frame-shift mutation in TREX1, an intracellular 3'-5' exonuclease 1. Hepatic findings include an elevated alkaline phosphatase (ALP) and nodular regenerative hyperplasia (NRH). Affected individuals typically succumb to brain lesions before clinically apparent hepatic manifestations; thus, little else is known about the hepatic pathology.
View Article and Find Full Text PDFVarious stem cell markers (eg, epithelial cell adhesion molecule [EpCAM], cytokeratin 19 [K19]) have been reported as predictors of poor prognosis in hepatocellular carcinoma (HCC). However, the data remain limited, particularly in Western populations, and are often contradictory. In this study, the prognostic value of positive SOX9 immunohistochemistry was compared with that of more established markers EpCAM and K19 in a large cohort (n=216) of North American patients.
View Article and Find Full Text PDFCandida tropicalisis an opportunistic fungal pathogen and is one of the most frequently isolated non-albicans species. It can cause localised as well as invasive systemic infections particularly in immunocompromised patients. Increased resistance to common anti-fungal drugs is an emerging problem.
View Article and Find Full Text PDF