Publications by authors named "E R Brody"
Article Synopsis
- - This study investigates how chronic psychological stress affects obesity in both youths and their parents, using an actor-partner interdependence model to see how stress levels relate to each other’s body weight.
- - Involving 569 pairs of youths and their parents, researchers assessed stress and measured body weight indicators like BMI and body fat percentage through interviews and measurements.
- - Findings indicate that both a youth's and a parent's chronic stress impact not only their own obesity but also each other's, highlighting the importance of the psychosocial environment in addressing obesity issues.
Article Synopsis
- Childhood socioeconomic disadvantage can lead to negative health outcomes, but factors promoting resilience, like neighborhood belonging, may help.
- A study with 245 adolescents explored how neighborhood belonging influences the link between socioeconomic disadvantage and low-grade inflammation, a marker for chronic diseases.
- Results showed that strong neighborhood belonging reduces the negative health impact of socioeconomic disadvantage, indicating that social connections are crucial for youth health resilience.
Observational studies in Parkinson's disease (PD) deeply characterize relatively small numbers of participants. The Molecular Integration in Neurological Diagnosis Initiative seeks to characterize molecular and clinical features of every PD patient at the University of Pennsylvania (UPenn). The objectives of this study are to determine the feasibility of genetic characterization in PD and assess clinical features by sex and GBA1/LRRK2 status on a clinic-wide scale.
View Article and Find Full Text PDFBackground: The GPNMB single-nucleotide polymorphism rs199347 and GBA1 variants both associate with Lewy body disorder (LBD) risk. GPNMB encodes glycoprotein nonmetastatic melanoma protein B (GPNMB), a biomarker for GBA1-associated Gaucher's disease.
Objective: The aim of this study was to determine whether GPNMB levels (1) differ in LBD with and without GBA1 variants and (2) associate with rs199347 genotype.
Animals constantly integrate sensory information with prior experience to select behavioral responses appropriate to the current situation. Genetic factors supporting this behavioral flexibility are often disrupted in neuropsychiatric conditions, such as the autism-linked gene which supports acoustically evoked habituation learning. encodes an AP2 endocytosis adaptor complex subunit, although its behavioral mechanisms and importance have been unclear.
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