Environmental Impact Assessment, Human Health and the Sustainable Development Goals.

Developmental processes influence the determinants of health and, consequently, human health. Yet, assessing human health impacts in impact assessment, with exception of health impact assessment, is still rather vague. Inclusion of Sustainable Development Goal indicators in environmental impact assessment (EIA) is an opportunity to enhance addressing human health in EIA practices.

Investigating the Oxidation Step in the CuCl-Catalyzed Aerobic Oxidative Coupling Reaction of -Aryl Tetrahydroisoquinolines.

The oxidative coupling of -aryl tetrahydroisoquinolines with nucleophiles has inspired the development of novel C-H functionalization reactions as well as mechanistic studies. Here, we investigate the oxidation step that forms iminium ions as key intermediates in the method using CuCl as the catalyst and oxygen as the terminal oxidant. A strong electronic effect of substituents in the N-aryl ring was found by synthetic studies and a Hammett plot analysis, supporting initial electron transfer from the amine to Cu(II).

Acid-Catalyzed Activation of Peroxyketals: Tunable Radical Initiation at Ambient Temperature and Below.

This study details how peroxyketals, commercially available thermal initiators, and structurally related peroxides are activated in the presence of an acid catalyst to generate radicals at room temperature and below. This simple combination of two substrates was shown to efficiently initiate a variety of radical processes. This phenomenon is rationalized by the acid-catalyzed in situ formation of highly unstable alkenyl peroxides which readily decompose into initiating radical species.

Reaction progress kinetic analysis of a copper-catalyzed aerobic oxidative coupling reaction with N-phenyl tetrahydroisoquinoline.

The results from a kinetic investigation of a Cu-catalyzed oxidative coupling reaction between N-phenyl tetrahydroisoquinoline and a silyl enol ether using elemental oxygen as oxidant are presented. By using reaction progress kinetic analysis as an evaluation method for the obtained data, we discovered information regarding the reaction order of the substrates and catalysts. Based on this information and some additional experiments, a refined model for the initial oxidative activation of the amine substrate and the activation of the nucleophile by the catalyst was developed.

A comparative mechanistic study of Cu-catalyzed oxidative coupling reactions with N-phenyltetrahydroisoquinoline.

A comparative mechanistic study of Cu-catalyzed oxidative coupling reactions of N-phenyltetrahydroisoquinoline with different nucleophiles was conducted. Two previously reported combinations of catalyst and oxidant were studied, CuCl(2)·2H(2)O/O(2) and CuBr/tert-butyl hydroperoxide (TBHP). On the basis of a synthetic study with different nucleophiles, the electrophilicity of the intermediate iminium ion was estimated and differences between the two methods were revealed.