Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study.

Unlabelled: Methylnaltrexone is effective for opioid-induced constipation (OIC) in advanced illness patients. This 4-week, double-blind, randomized, placebo-controlled study investigated the effect of subcutaneous methylnaltrexone on OIC in patients receiving opioids for chronic, nonmalignant pain. Patients (N = 460) received subcutaneous methylnaltrexone 12 mg once daily (QD) or every other day (alternating with placebo) compared with placebo.

A multicenter, randomized, double-blind, controlled study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia.

Objectives: To confirm the efficacy, tolerability, and safety of NGX-4010, an 8% capsaicin dermal patch (capsaicin 640 µg/cm(2) ), in patients with postherpetic neuralgia (PHN). PHN is a chronic pain disorder that can be difficult to treat and for which current treatment options are often limited by poor tolerability.

Design: A total of 418 patients were randomized to receive a single 60-minute application of NGX-4010 or a 0.

NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study.

Background: The limitations of current treatments for postherpetic neuralgia (PHN) have led to the investigation of localised, non-systemic alternatives. NGX-4010, a high-concentration (8%) capsaicin dermal patch, was developed to treat patients with neuropathic pain. We report the results of a randomised, double blind, 12-week study of the efficacy and safety of one application of NGX-4010 in patients with PHN.

The incremental validity of lumbar surface EMG, behavioral observation, and a symptom checklist in the assessment of patients with chronic low-back pain.

This study evaluated the comparative ability of lumbar surface EMG, behavioral observation, and a symptom checklist to correctly classify three groups of participants, (1) 18 patients with chronic low-back pain (CLBP), demonstrating excessive and/or anatomically inconsistent motor, sensory, and tenderness responses during a neurological examination, (2) 33 patients with CLBP exhibiting few or no inconsistent responses, and (3) 30 healthy matched controls. Discriminant analyses were used to develop predictive models. Correct classification rates for the individual assessments and all combinations of assessments were contrasted.