Publications by authors named "E Quadros"
Article Synopsis
- The study aimed to estimate the levels of various metallic elements in the blood of people living near a Steel company in Santa Cruz, Brazil, and to see if living close to the company was linked to higher metal concentrations.
- A total of 463 residents aged 18 and older were analyzed, measuring metals like Cadmium (Cd) and Lead (Pb) through blood samples, and distances from their homes to the Steel company were recorded using GPS.
- The results showed that for every kilometer further from the Steel company, there was a 19% decrease in blood levels of harmful metals like Cd, Al, and Pb, suggesting lower exposure with increased distance, while no significant links were found for other metals after adjustments.
Autism spectrum disorder (ASD) affects up to 1 in 36 children in the United States. It is a heterogeneous neurodevelopmental disorder with life-long consequences. Patients with ASD and folate pathway abnormalities have demonstrated improved symptoms after treatment with leucovorin (folinic acid), a reduced form of folate.
View Article and Find Full Text PDFVitamin B (B) deficiency causes neurological manifestations resembling multiple sclerosis (MS); however, a molecular explanation for the similarity is unknown. FTY720 (fingolimod) is a sphingosine 1-phosphate (S1P) receptor modulator and sphingosine analog approved for MS therapy that can functionally antagonize S1P. Here, we report that FTY720 suppresses neuroinflammation by functionally and physically regulating the B pathways.
View Article and Find Full Text PDFB vitamins as a group play essential roles in a multitude of metabolic reactions involved in cellular replication, energy production, the synthesis of intermediary compounds, and neurotransmitters [...
View Article and Find Full Text PDFBackground & Aims: Cellular uptake of the essential nutrient vitamin B12 (cobalamin) occurs via the transcobalamin receptor (TCblR/CD320), a ubiquitous membrane receptor. Polymorphisms in the receptor exist, though the effect of such variants across patient populations is unknown.
Methods: We determined CD320 genotype in 377 randomly selected elderly individuals.