The Frequency of c.557A>G in the Dominican Population and Its Association with African Ancestry.

Genetic polymorphism of the dihydropyrimidine dehydrogenase gene () is responsible for the variability found in the metabolism of fluoropyrimidines such as 5-fluorouracil (5-FU), capecitabine, or tegafur. The genotype is linked to variability in enzyme activity, 5-FU elimination, and toxicity. Approximately 10-40% of patients treated with fluoropyrimidines develop severe toxicity.

Visual Performance After Bilateral Implantation of a New Enhanced Monofocal Hydrophobic Acrylic Intraocular Lens Targeted for Mini-Monovision.

Background: The aim of this study was to evaluate visual outcomes and patient satisfaction after bilateral implantation of a new hydrophobic acrylic intraocular lens called Clareon (Alcon) using the mini-monovision technique.

Methods: A single-center, prospective, nonrandomized study was conducted in Tandil (Buenos Aires, Argentina), including patients scheduled for cataract surgery. To achieve mini-monovision, the spherical equivalent was calculated between -0.

Evaluation of the recombinant protein -TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests.

Different agencies have emphasized the need to evaluate current serological methods for screening patients with suspected urogenital schistosomiasis. However, there is still a lack of evidence regarding the most appropriate methods for this purpose. Here we assessed the diagnostic efficacy of a newly developed serological technique that utilizes the recombinant protein -TSP-2, applied to the urine and serum of migrants suspected of having urogenital schistosomiasis.

Beyond secondary prevention drugs: Added benefit in survival and events of a healthy lifestyle in patients after an acute coronary syndrome.

Objective: To quantify the added clinical benefit of a healthy lifestyle following an acute coronary syndrome (ACS). Our study seeks to answer the question: Is adherence to medical therapy sufficient or a healthy lifestyle provides additional improvement?.

Methods: This is a prospective observational multi-center study of 685 ACS patients.

Mesoporous Silica Nanoparticle Rigid Anchor Attached Pt Complex for Catalytic H/D Exchange of Aromatic Substrates.

A Pt(II) aqua complex supported by mesoporous silica nanoparticle (MSN)-immobilized sulfonated CNN pincer ligand featuring a rigid SiO tether was prepared. This hybrid material was tested as a catalyst in H/D exchange reactions of C(sp)-H bonds of selected aromatic substrates and DO-2,2,2-trifluoroethanol- (TFE-) mixtures or CDCOD acting as a source of exchangeable deuterium. The catalyst immobilization served as a means to not only enable the catalyst's recyclability but also minimize the coordination of sulfonate groups and the metal centers originating from different catalyst's moieties that would preserve reactive Pt(OH) fragments needed for catalytic C-H bond activation.