Publications by authors named "E Pullenayegum"
A Bayesian latent class approach to causal inference with longitudinal data.
Stat Methods Med Res
December 2024
Bayesian methods are becoming increasingly in demand in clinical and public health comparative effectiveness research. Limited literature has explored parametric Bayesian causal approaches to handle time-dependent treatment and time-dependent covariates. In this article, building on to the work on Bayesian g-computation, we propose a fully Bayesian causal approach, implemented using latent confounder classes which represent the patient's disease and health status.
View Article and Find Full Text PDFObjective: We identified factors associated with computed tomographic (CT) imaging within 24 hours of emergency department (ED) presentation in hospitalized children with severe orbital infections.
Patients And Methods: A multicenter retrospective cohort study was conducted that included children aged 2 months to 18 years between 2009 and 2018 who were admitted to the hospital with severe orbital infections, including periorbital and orbital cellulitis. Multivariable modified Poisson regression was used to identify possible factors associated with receiving a CT scan within 24 hours of ED presentation.
Background: The use of EQ-5D instruments in clinical, policy and economic applications continues to grow internationally. Population norms studies provide baseline values against which demographic and patient groups are compared and inequality is assessed. This study presents updated EQ-5D-5L population norms for 2022-2023, evaluates inequality and compares the results with those of 2012.
View Article and Find Full Text PDFArticle Synopsis
- Preterm birth (PTB) is a significant cause of neonatal mortality and is associated with higher risks of death later in life, but research on long-term outcomes in North America is limited.
- This study analyzed data from nearly 5 million births in Canada between 1983 and 1996 to investigate the link between PTB and mortality from birth to age 36.
- Findings revealed that individuals born preterm had a significantly increased risk of death across all age groups, especially in infancy, highlighting the long-term implications of PTB on health.
Background: Hemagglutinin (HA)-inhibiting antibodies contribute to the immune defense against influenza infection. However, there are insufficient data on the extent of correlation between vaccine-elicited HA antibodies and protection in children against different influenza strains, particularly when comparing live attenuated influenza vaccines (LAIV) versus inactivated influenza vaccines (IIV).
Methods: We measured postvaccination hemagglutination-inhibition (HAI) titers in 3-15-year-old participants of a cluster-randomized controlled trial of trivalent LAIV(3) versus IIV(3) in Canadian Hutterite colonies.