Revealing Alzheimer's Disease Dementia Patterns in [18F]Florbetapir PET with Independent Component Analysis.

This study investigates Alzheimer's Disease (AD) dementia through [18F]Florbetapir ([18F]FBP) Positron Emission Tomography (PET) imaging. We employ Independent Component Analysis (ICA) to identify shared latent patterns across controls and individuals with Dementia. The dataset comprises PET brain images from 440 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI).

Predicting survival rate by plasma biomarkers and clinical variables in syndromes associated with frontotemporal lobar degeneration.

Introduction: Modeling the survival rate in syndromes associated with frontotemporal lobar degeneration (FTLD) is essential to assess disease trajectories.

Methods: In 262 patients with FTLD, we considered plasma neurofilament light chain (NfL), glial fibrillary acidic protein, brain-derived tau, phosphorylated tau217 and amyloid beta (Aβ42/Aβ40). The FTLD Survival Score (FTLD-SS) was calculated by the β coefficients of the variables independently associated with survival rate.

Dopaminergic deficits along the spectrum of Alzheimer's disease.

Both post-mortem and in vivo data argue for dopamine dysfunction in patients with Alzheimer's Disease (AD). However, the timing and regional progression of dopaminergic systems alterations in AD are still debated. The aim of the study was to investigate in vivo the pattern of dopaminergic changes and connectivity using DAT-SPECT imaging in patients across the AD spectrum.

Loss of Insight in Syndromes Associated with Frontotemporal Lobar Degeneration: Clinical and Imaging Features.

Objectives: The present study aims to assess the prevalence, associated clinical symptoms, longitudinal changes, and imaging correlates of Loss of Insight (LOI), which is still unexplored in syndromes associated with Frontotemporal Lobar Degeneration (FTLD).

Design: Retrospective longitudinal cohort study, from Oct 2009 to Feb 2023.

Setting: Tertiary Frontotemporal Dementia research clinic.

Impaired spatial dynamic functional network connectivity and neurophysiological correlates in functional hemiparesis.

The present study investigated spatial dynamic functional network connectivity (dFNC) in patients with functional hemiparesis (i.e., functional stroke mimics, FSM).